A new antiviral 14-nordrimane sesquiterpenoid from an endophytic fungus Phoma sp.

Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Si-Si Liu, Ju-Xing Jiang, Rong Huang, Ya-Ting Wang, Bo-Guang Jiang, Kai-Xuan Zheng, Shao-Hua WuAbstractA new rare 14-nordrimane-type sesquiterpenoid, named phomanolide (1), together with five known compounds, (–)-6-methoxymellein (2), 7-hydroxy-3, 5-dimethyl-isochromen-1-one (3), norlichexanthone (4), 6-methylsalicylic acid (5), and gentisyl alcohol (6), were obtained from the culture broth of an endophytic fungus Phoma sp. isolated from the roots of Aconitum vilmorinianum. The structure of compound 1 was established based on extensive spectroscopic analysis. Compound 1 was the first example of 14-nordrimane-type sesquiterpene up to now. Compounds 1 and 2 showed antiviral activities against influenza A virus (A/Puerto Rico/8/34, H1N1) with IC50 values of 2.96 ± 0.64 and 20.98 ± 2.66 μg/mL, respectively.Graphical abstract

Source: Phytochemistry Letters - November 22, 2018 Category: Chemistry Source Type: research