CHIT1 is a novel therapeutic target in idiopathic pulmonary fibrosis (IPF): anti-fibrotic efficacy of OATD-01, a potent and selective chitinase inhibitor in the mouse model of pulmonary fibrosis
Conclusion: We have demonstrated that expression of CHIT1 is increased in IPF and that inhibition of chitinases with OATD-01 provided significant therapeutic efficacy, comparable to nintedanib, in the bleomycin-induced pulmonary fibrosis model. These data support further development of OATD-01 as a first-in-class therapy for IPF.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Dymek, B., Sklepkiewicz, P., Mlacki, M., Zagozdzon, A., Koralewski, R., Mazur, M., Paplinska-Goryca, M., Nejman-Gryz, P., Proboszcz, M., Gorska, K., Maskey-Warzechowska, M., Przysucha, N., Krenke, R., Golebiowski, A., Dobrzanski, P., Dzwonek, K. Tags: Idiopathic interstitial pneumonias Source Type: research
More News: Respiratory Medicine