Unraveling the role of miR-223-3p in the regulation of airway inflammation in asthma

In conclusion, we confirmed increased expression of miR-223-3p in airways of asthma patients compared to healthy controls. Overexpression of miR-223-3p in human bronchial epithelial cells resulted in higher CCL20 levels. This suggests that increased levels of miR-223-3p in asthma, e.g. when secreted in exosomes may contribute to the release of the pro-inflammatory CCL20 by airway epithelial cells.

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Roffel, M., Boudewijn, I., Guryev, V., Brandsma, C.-A., Van Den Berge, M., Bracke, K., Maes, T., Heijink, I. Tags: Allergy and immunology Source Type: research