The effect of inhaled lung volume on ventilation heterogeneity in CF using 3He MRI

Conclusion: The ventilation MRI metrics VDP and CV decrease at TLC and correlate with LCI and FEV1. Reversible ventilation defects identified by deep inspiration may correspond to slow-ventilation regions during MBW. Using fixed inhaled bag volumes for ventilation MRI may lead to underestimation of ventilation defects in smaller subjects.

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Smith, L., Collier, G., Marshall, H., Hughes, P., Bray, J., Rodgers, O., Aldag, I., West, N., Wildman, M., Horsley, A., Wild, J. Tags: Cystic fibrosis Source Type: research