Analysis of Immunoglobulin A and M gene expression and plasma cells in bronchial tissue from COPD patients with high blood eosinophil counts

Conclusions: COPD patients with higher blood eosinophils, have more IgA, IgM and increased plasma cell gene signature in the bronchial airway. While this may play a role in reducing bacterial colonisation in these patients, further work is required to determine if this is a direct role of eosinophils or whether this is secondary to the higher, local inflammation observed in eosinophilic COPD patients.

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Southworth, T., Kolsum, U., Higham, A., Sridhar, S., Pham, T.-H., Newbold, P., Singh, D. Tags: Airway Cell Biology and Immunopathology Source Type: research