Effect of polymorphism of Toll-like receptor genes on the duration of pulmonary tuberculosis

The aim of the study was to examine the impact of genetic polymorphism of the genes TLR2 (Arg753Gln), TLR3 (Phe412Leu), TLR4 (Asp299Gly), TLR6 (Ser249Pro) on the duration of tuberculosis. The material for the study was DNA. Statistical processing was carried out using the program "Statistica 10". The risk of events was assessed by the odds ratio (OR). The study was conducted in Chita Regional pulmonology center. 120 patients with respiratory tuberculosis and 30 healthy recipients were examined. The average age of the subjects was 44.1+0.3 years. Depending on the duration of the disease, 3 groups of patients were formed: the first (77 persons) - who have not experienced more than 6 months from the time of the appearance of the disease; 2nd (21 people) - with the duration of the disease from 6 to 24 months; 3rd (22 people) - with the presence of the disease for more than 2 years. In group 1, the carrier of a mutant variant of the Pro/Pro polymorphism of the TLR6 gene (Ser249Pro) was found among patients with tuberculosis - and was 10% (8 recipients) (p <0.05) [OR1=7.46 CI 95% (0.42 to 133, 41)]. In the second group, mutant variants of polymorphism of the gene TLR 6 (Ser249Pro) (p <0.03) were found [OR1=1.42 CI 95% (0.03 to 74.32)]. In the third group the mutant allele TLR 3 (Phe412Leu) was characteristic only for patients (p <0.07) [OR1=1.18 CI 95% (0.03 to 74.32)]. Thus, it can be assumed that the presence of mutant Toll-like receptor genes is not a predisposing facto...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research