Enhanced endothelial barrier protective and anti-inflammatory effects by synthetic iloprost-conjugated phospholipid.

In conclusion, this study describes a novel synthetic phospholipid with barrier-enhancing and anti-inflammatory properties superior to existing prostacyclin analogs, which may be used as a prototype for future development of more efficient treatment for ALI and other vascular leak syndromes.

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Birukov, K., Oskolkova, O., Li, Y., Zhang, C.-O., Gawlak, G., Ke, Y., Birukova, A. Tags: Mechanisms of Lung Injury and Repair Source Type: research