A major inflammatory cytokine TNF-a inhibits the ventilatory response to hypoxia

It is known that the systemic level of the major pro-inflammatory cytokine increases in many respiratory diseases such as asthma, COPD and sleep apnea. The lung ventilation changes and the pathological types of breathing are typical in these diseases. By the reason, the increasing cytokine level research is actual.The aim of the present study was to examine the hypothesis that elevation of major pro-inflammatory cytokine TNF-α systemic level may decrease the ventilatory response to hypoxia.The experiments were performed in tracheostomized anaesthetized rats. The hypoxic ventilatory response was measured by using rebreathing with hypoxic gas mixture before and after the tail vein injection of TNF-α(10mcg/rat).We have shown that the increase in level of TNF-α in blood weakens the ventilatory responses to hypoxia. The slope of the hypoxic ventilatory response decreased from 6.06±0.91 to 3.48±0.38 mL/min–1 mmHg–1 (-40%) 40 min after administration of TNF-α(p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Mechanisms of Lung Injury and Repair Source Type: research

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The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily variance. This prompted us to examine the interaction between the hypoxic response and the circadian clock in vivo. We found that the global transcriptional response...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
ConclusionsHospitalization for HRF is associated with a high morbidity and mortality. Our observation that home oxygen use was associated with increased mortality suggests that oxygen use could be a risk factor for death in patients with HRF.
Source: Lung - Category: Respiratory Medicine Source Type: research
Purpose of review Severe asthma is often associated with numerous comorbidities that complicate disease management and affect patient's outcomes. They contribute to poor disease control and mimic asthma symptoms. Although some comorbidities such as obstructive sleep apnea, bronchiectasis, and chronic obstructive pulmonary disease are generally well recognized, many other may remain undiagnosed but may be detected in an expert specialist setting. The management of comorbidities seems to improve asthma outcomes, and optimizes therapy by avoiding overtreatment. The present review provides recent knowledge regarding the most...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: ASTHMA: Edited by Nicola A. Hanania, Zuzana Diamant, and Maarten van den Berge Source Type: research
Sleep apnea lead to sudden death associated with breathing during sleep(Kim et.al,2015)Aim: To investigate sleep apnea status and related factors in patients with respiratory failureMethod: The sampleof study consists of 86 people who received treatment in chest clinic and voluntarily agreed to participate. Data were collected by using interview form with sociodemographic characteristics, Pittsburg Sleep Quality Index, Berlin Sleep Apnea IndexResult: The mean age was 58±12, 66,3%were male, 55.8%had quit smoking due to disease.54.7%of the participants had COPD,26.7% had pneumonia,10.5%had asthma. 67.4%of patients had...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory function technologists/scient. Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Occupational and environmental health Source Type: research
Conclusions: In our sample, expensive SC medication was one of the main barriers, since in Portugal varenicline is the only reimbursed prescription drug to SC. Higher levels of anxiety and choosing the wrong time to quit hindered the success of SC. Handing out self-reported questionnaires is a possible way to identify barriers to SC and improve the success of SC programs.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tobacco, smoking control and health educ. Source Type: research
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Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
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Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
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