Effects of comorbidities on physical activity in chronic obstructive pulmonary disease

Physical activity has been reported to be reduced in patients with chronic obstructive pulmonary disease (COPD), which is associated with higher risks of exacerbation and mortality. Physical inactivity in COPD can be affected not only by lung function, but also by extra-pulmonary comorbidities.We conducted a cross-sectional study with a series of tests including lung function, physical activity, and comorbidities. Eighty outpatients with stable COPD were recruited, and relationship between comorbidities and physical activity was evaluated. Physical activity was assessed through 14 consecutive days by a triaxial accelerometer, which records total daily energy expenditure. Cardiovascular status was assessed by echocardiography, and pulmonary artery pressure was estimated by Doppler sonography. Exercise capacity was evaluated by 6-minutes walking distance. As to mental status, depression and anxiety were assessed by Self-rating Depression Scale and State-Trait Anxiety Inventory, respectively.Parameters of comorbidities associated with physical inactivity in patients with COPD were as follow; elevated pulmonary artery pressure, reduced exercise capacity, low body mass index, muscle weakness of upper and lower limbs, depression and anxiety.These findings suggest that physical inactivity is affected by multiple factors including pulmonary hypertension, skeletal muscle dysfunction and depressive/anxious symptoms in COPD patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research