Lung Cancer Screening Programs: a missed "window" to diagnose Obstructive Lung Disease. The NLST-ACRIN experience.

Background: Undiagnosed obstructive lung disease (OLD) is common (around 70%) among American adults. Lung Cancer Screening Programs provide a unique opportunity to diagnose OLD in a high risk population.Objective: To determine the proportion of undiagnosed and miss-diagnosed OLD.Methods: We explored the NLST-ACRIN database that included 13831 smokers, age 55-74 yrs with at least 30 pack-years history that underwent a spirometry. OLD was defined per GOLD criteria with a FEV1/FVC ratio
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research

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The aim of this study was to determine the role of physiological measurements in the evaluation of postoperative risks before lung cancer surgery. Spirometry and ABG were performed for all patients with NSCLC before operation. Diffusion test and CPET were performed to patients with moderate-high risk for operation and the patient who required pneumonectomy. Postoperative complications, mortality and duration of stay in ICU and hospital were recorded.115 NSCLC patients who had limited lung capacity(22F,93M) with a mean age of 62.37±10.11 were included prospectively between Jan2015-Dec2018. 54(46.9%) patients were acc...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Thoracic surgery Source Type: research
Background: Chronic bronchitis (CB) plays a role in the incidence of acute exacerbations (AE) and disease progression in COPD. However, the role of CB in the overall mortality in smokers is not completely understood.Aim: To investigate: the contribution of CB to morbidity and mortality in smokers with and without COPD; the relation of CB with blood cell count.Methods: 512 smokers (303 with and 209 without COPD) were followed for 5 years with clinical evaluation, spirometry and blood samples. The effects of CB in the clinical outcomes of smokers with and without COPD were studied.Results: 193 subjects (38%) had CB and 319 (...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Conclusion: SpiroNose data obtained by tidal breaths and VC manoeuvres are not interchangeable. VC manoeuvres provide the highest accuracies in the cross comparison of controls and asthma, COPD and lung cancer patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory function technologists/scient. Source Type: research
Conclusion: COPD group had lower decrease of VO2PEAK and increase the VE/VCO2RCP intercept after surgery.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
Conclusion: The COPD group had an overestimation of post-operative functional loss.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
ABSTRACT Objective: Preoperative functional evaluation is central to optimizing the identification of patients with non-small cell lung cancer (NSCLC) who are candidates for surgery. The minute ventilation/carbon dioxide output (VE/VCO2) slope has proven to be a predictor of surgical complications and mortality. Pulmonary rehabilitation programs (PRPs) could influence short-term outcomes in patients with COPD undergoing lung resection. Our objective was to evaluate the effects of a PRP on the VE/VCO2 slope in a cohort of patients with COPD undergoing lung resection for NSCLC. Methods: We retrospectively evaluated 25 consec...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
Authors: Okada Y, Hashimoto N, Iwano S, Kawaguchi K, Fukui T, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y Abstract Although the lower limit of normal (LLN) of FEV1/FVC detects at-risk patients for postoperative outcomes among Japanese chronic obstructive pulmonary disease (COPD) patients with resected lung cancer, there was a lack of a Japanese reference equation to calculate the LLN of FEV1/FVC. Renewed Japanese spirometric reference variables might enable us to verify clinical impact of the LLN of FEV1/FVC among the Japanese population. To evaluate the clinical impact of the LLN of FEV1/FVC by using this renewed ref...
Source: Nagoya Journal of Medical Science - Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research
A major U.S. tobacco company on Saturday issued a press release boasting that smoking its cigarettes is no more harmful than vaping an e-cigarette that contains no tobacco and involves no combustion, at least in terms of lung disease. A spokesperson for the company was kind enough to allowThe Rest of the Story to interview him. The transcript appears below, with only slight editing for purposes of clarity. I was given permission to publish the interview, but under the condition that I not name the spokesperson.The Rest of the Story: Let me first make sure I have this correctly. You are saying that in terms of lung disease,...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
Yafei Tan1,2, Omer Van den Bergh2, Jiang Qiu1* and Andreas von Leupoldt2* 1Faculty of Psychology, Southwest University, Chongqing, China 2Health Psychology, KU Leuven, Leuven, Belgium Dyspnea is a prevalent interoceptive sensation and the aversive cardinal symptom in many cardiorespiratory diseases as well as in mental disorders. Especially the unpredictability of the occurrence of dyspnea episodes has been suggested to be highly anxiety provoking for affected patients. Moreover, previous studies demonstrated that unpredictable exteroceptive stimuli increased self-reports and electrophysiological responses of an...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
The increasingly female face of chronic obstructive pulmonary disease (COPD) prevalence among women has equalled that of men since 2008, due in part to increased tobacco use among women worldwide and exposure to biomass fuels. This finding is supported by a number of characteristics. There is evidence of susceptibility to smoking and other airborne contaminants, along with epidemiological and phenotypic manifestations. COPD has thus become the leading cause of death in women in the USA. The clinical presentation is characterised by increasingly pronounced dyspnoea with a marked tendency towards anxiety and depression, unde...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: COPD and smoking Review Source Type: research
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