The causes of the delay in diagnosis bronchopulmonary cancer

This study aimed to determine the different delays in the management of lung cancers through a retrospective descriptive and analytical study on 131 hospitalized cases in service between April 2014 and January 2017. Management delays were estimated from the date of the first symptom described by the patient (D1s), the first contact with health care provider (1Cs), then hospitalization (DH) and finally to the histological confirmation of the diagnosis (C Hist) before the start of treatment (D ttt).Among the patients included in our work, 90.8% were men, 87.8% were chronic smokers. The mean age was 61 years; chest pain was the most frequent symptom (75.6% of cases). The most common histological type was non-small cell lung carcinoma of which 55.9% were adenocarcinoma. The stage IV has found in 59% of patients at the time of diagnosis.The median time of consultation (D1s to 1Cs) was 48 days, the median diagnosis time (DH to C Hist) was 20 days and the median therapeutic time (C Hist to Dttt) was 11 days. The median global wait time (D1s to Dttt) was 127 days. The factors associated with a diagnostic delay were women, non-smokers and patients with extra-respiratory signs. Our work is in invitation to produce others studies to compare the delays in several regions of morocco as a function of various parameters. This will allow obtaining a broad base of national data and establishing national recommendations adapted to our context.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research

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AbstractAimWe designed a prospective randomized study to assess the outcome of Colorado microdissection needle in comparison with conventional surgical blade for performing neck dissections.Materials and MethodsSixty patients who underwent neck dissection for oral cancers were randomly allocated into two groups. The outcome measurements were in terms of cosmetic outcome of neck scar, intraoperative blood loss, over all operative time, and postoperative neck drain assessment.ResultsThe use of microdissection needle in performing skin incision and neck dissection eliminates the need for local anesthetic with vasoconstrictor ...
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
ConclusionChlorhexidine diacetate-impregnated polyglactin sutures showed reduced erythema, pain and trismus in healthy patients undergoing surgical removal of third molar.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
CONCLUSION: Propofol ameliorates NP and neuroinflammation of rats by up-regulating PPAR γ expression to block the Wnt/β-catenin pathway. PMID: 32985377 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
This study aims to investigate the efficacy and mechanism of action of TG-C in a rat model of OA. Using the monosodium-iodoacetate (MIA) model of OA, we examined whether TG-C could improve OA symptoms and cartilage structure in rats. Our results showed that TG-C provided pain relief a nd cartilage structural improvement in the MIA OA model over 56 days. In parallel with these long-term effects, cytokine profiles obtained on day 4 revealed increased expression of interleukin-10 (IL-10), an anti-inflammatory cytokine, in the synovial lavage fluid. Moreover, the increased levels of TGF-β1 and IL-10 caused by TG-C in...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: An environmental and community health approach, such as PEHis, in CCS long-term programs promoting the creation of healthier environments and lifestyles contributes to improving their HRQoL and secondarily other chronic diseases. PMID: 32980005 [PubMed - in process]
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
CONCLUSIONS: Exposure to elevated solar UVR levels is common among outdoor workers in Alberta. The study findings can help inform future monitoring studies and exposure reduction initiatives aimed at protecting workers. PMID: 32980002 [PubMed - in process]
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
Abstract Chemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the 'epitranscriptome', with 6-methyladenosine (m6A), 5-methylcytidine (m5C), pseudouridine and N1-methyladenosine (m1A) the most extensively investigated. Although we are just beginning to elucidate the roles of these modifications in cellular functions, there is already evidence for thei...
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
This study intended to determine the bioburden present in MPG and their biological effects, and to discuss the possibility to use MPG as a passive method to assess occupational exposure to microbial contamination. Fungal burden was characterized through molecular tools for fungal toxigenic species, and antifungal resistance and mycotoxins profiles were determined. Cell viability was determined in swine kidney (SK) monolayer and hepatocellular carcinoma (Hep G2) cell lines. All MPG samples presented Gram-negative bacteria. The fungal contamination ranged from 0 CFU.m-2 in both MEA and DG18, to 5.09 × 10...
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
We describe a 63-year-old female who was presented with obstructive jaundice and epigastric pain of 10 days. Initial CBC revealed 43x103/ μL white blood cells, 11.2 g/dL hemoglobin, and 88x103/ μL platelets. CT abdomen revealed hepatomegaly and suspected pancreatic mass with large retroperitoneal lymph nodal mass. Peripheral smear showed 56% lymphoid cells with blast morphology. The bone marrow (BM) aspirate smear was infiltrated by 83% immature-looking cells. BM biopsy showed interstitia l to diffuse extensive infiltration by primitive-looking cells, positive for pan-B-cell antigens CD20, CD79, and PAX5 as well as t...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Liu Y, Wang X, Yang Y Abstract Primary liver cancer is one of the most common cancer worldwide. Hepatocellular carcinoma (HCC) in particular, is the second leading cause of cancer deaths in the world. The Hippo signaling pathway has emerged as a major oncosuppressive pathway that plays critical roles inhibiting hepatocyte proliferation, survival, and HCC formation. A key component of the Hippo pathway is the inhibition of yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) transcription factors by the Hippo kinase cascade. Aberrant activation of YAP or TAZ has been found ...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
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