The causes of the delay in diagnosis bronchopulmonary cancer

This study aimed to determine the different delays in the management of lung cancers through a retrospective descriptive and analytical study on 131 hospitalized cases in service between April 2014 and January 2017. Management delays were estimated from the date of the first symptom described by the patient (D1s), the first contact with health care provider (1Cs), then hospitalization (DH) and finally to the histological confirmation of the diagnosis (C Hist) before the start of treatment (D ttt).Among the patients included in our work, 90.8% were men, 87.8% were chronic smokers. The mean age was 61 years; chest pain was the most frequent symptom (75.6% of cases). The most common histological type was non-small cell lung carcinoma of which 55.9% were adenocarcinoma. The stage IV has found in 59% of patients at the time of diagnosis.The median time of consultation (D1s to 1Cs) was 48 days, the median diagnosis time (DH to C Hist) was 20 days and the median therapeutic time (C Hist to Dttt) was 11 days. The median global wait time (D1s to Dttt) was 127 days. The factors associated with a diagnostic delay were women, non-smokers and patients with extra-respiratory signs. Our work is in invitation to produce others studies to compare the delays in several regions of morocco as a function of various parameters. This will allow obtaining a broad base of national data and establishing national recommendations adapted to our context.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research

Related Links:

Authors: Pfeifer CR, Irianto J, Discher DE Abstract As a cancer cell invades adjacent tissue, penetrates a basement membrane barrier, or squeezes into a blood capillary, its nucleus can be greatly constricted. Here, we examine: (1) the passive and active deformation of the nucleus during 3D migration; (2) the nuclear structures-namely, the lamina and chromatin-that govern nuclear deformability; (3) the effect of large nuclear deformation on DNA and nuclear factors; and (4) the downstream consequences of mechanically stressing the nucleus. We focus especially on recent studies showing that constricted migration caus...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Schumacher L Abstract Collective cell migration is a key process in developmental biology, facilitating the bulk movement of cells in the morphogenesis of animal tissues. Predictive understanding in this field remains challenging due to the complexity of many interacting cells, their signalling, and microenvironmental factors - all of which can give rise to non-intuitive emergent behaviours. In this chapter we discuss biological examples of collective cell migration from a range of model systems, developmental stages, and spatial scales: border cell migration and haemocyte dispersal in Drosophila, gastrula...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Banerjee S, Marchetti MC Abstract Collective cell migration plays a central role in tissue development, morphogenesis, wound repair and cancer progression. With the growing realization that physical forces mediate cell motility in development and physiology, a key biological question is how cells integrate molecular activities for force generation on multicellular scales. In this review we discuss recent advances in modeling collective cell migration using quantitative tools and approaches rooted in soft matter physics. We focus on theoretical models of cell aggregates as continuous active media, where the...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Yang Y, Jolly MK, Levine H Abstract Collective cell migration plays key roles in various physiological and pathological processes in multicellular organisms, including embryonic development, wound healing, and formation of cancer metastases. Such collective migration involves complex crosstalk among cells and their environment at both biochemical and mechanical levels. Here, we review various computational modeling strategies that have been helpful in decoding the dynamics of collective cell migration. Most of such attempts have focused either aspect - mechanical or biochemical regulation of collective cel...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSION: In this review, the recent findings about the renoprotective agents were evaluated and screened with respect to the use of 99mTc-DMSA , which is preclinically and clinically used for animal cases and cancer patients under the treatment by radiotherapy and chemotherapy. PMID: 31612808 [PubMed - in process]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research
Conclusion: These observations disclosed that Ras-ERK1/2 promoted the development of lung cancer via decreasing H3K18ac through MDM2-mediated GCN5 degradation. These findings might provide a new therapeutic strategy for lung cancer. PMID: 31613681 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ02990G, PaperXin Fu, Hua-qin Zhang, JUN Zhao, Lu-lu Yu, Qing-rong Liang, Yu Zhang, xiuguang yi, yong-xiu Li, Ji-long Hu, yuanqiao he, Qun Tang Colloidal gadolinium arsenite has been developed as arsenic trioxide nanoparticle prodrug (ATONP) by our group in the past five years, and it has illustrated highly promising for cancer therapy. Here... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
University of Rochester Medical Center researchers have been selected as part of a national initiative by the National Institutes of Health to develop new non-addictive treatments for pain to improve patient care and curb the use and abuse of opioids.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news
Got a link?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
ConclusionRACRS is safe in the treatment of patients with stage I –III colorectal cancer. Oncological outcome did not differ between RACRS and LCRS groups. RACRS had lower conversion and intra-operative complication rates.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
More News: Adenocarcinoma | Cancer | Cancer & Oncology | Carcinoma | Chronic Pain | Health Management | International Medicine & Public Health | Lung Cancer | Morocco Health | Non-Small Cell Lung Cancer | Pain | Pain Management | Respiratory Medicine | Smokers | Study | Women