Comparison of endobronchial ultrasound-guided transbronchial needle aspiration and positron emission tomography standard uptake values in mediastinal or hilar lymph node evaluation in benign, granulomatous and malignant disease

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and positron emission tomography (PET) standard uptake values (SUV) are useful methods for evaluating mediastinal lymph node pathology.The aim this study was to compare EBUS TBNA and PET suv results in benign, granulomatous and malignant disease. The files of 151 patients who had FDG-PET scanning and underwent EBUS-TBNA between 2015-2017 were reviewed. The diagnoses were confirmed by needle aspiration cytology, histopathology and clinical follow-up. Malignant diseases included lung cancers, metastasis and lymphomas. Granulomatous diseases were mainly sarcoidosis and tuberculosis. Benign group comprised mainly of patients suspected with relapse of malignancy in whom it was disproved or no specific diagnosis was reached during follow-up.The patients included 101 males and 50 females with mean age 58.64±12.46 (26-86). A total of 356 stations were sampled with an average of 2.36 stations per case. Malignancy was observed in 100 lymph nodes with a mean SUV of 10.96±7.00 (range 3.3-60) and diameter 23.58±7.84mm (10-40mm). Granulomas were present in 53 lymph nodes with mean SUV 8.82±4.83 (range 3.4-25) and diameter 21.44±18.30mm (10-35mm). Benign lymph nodes had a mean SUV 6.13±3.20 (range 1.7-15.4), and diameter 15.53±6.69mm (5-30mm). Although the comparison of suv and diameters have yielded significant difference with p<0.001 for both, the presence of co...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research