Tuberculosis in pregnant and postpartum women.

Tuberculosis (TB) is one of most important non-obstetric causes of maternal death. The aim of study was to estimate TB morbidity in pregnant and postpartum women (PW) in Gomel region as well as risk factors and level of drug resistance. Proportions are presented with 95% CI computed by the modified Wald method. We studied all new cases of lung TB found in PW in 2013-2016 - 51 patients, the proportion was 11.2% (8.5-14.5) of all women aged 18-45. TB incidence was 50.9 per 100000 deliveries which is reliably higher than in control group (women aged 18-45 excepting PW, TB incidence was 31,6 per 100000 women), p=0.03. 19.6% (10.8-32.7) of PW were HIV-positive. Among HIV-negative PW 2.4% (0.8-12.3) had diabetes, 2.4% (0.8-12.3) had bronchial asthma, 2.4% (0.8-12.3) were alcohol addicted, and 4.8% (6.0-16.5) had contact with a smear-positive TB patient while being pregnant. In 92.1% (80.9-97.4) women TB was found by X-ray screening after delivery. In 7.8% (2.6-19.0) patients TB was found during pregnancy by X-ray examination. In all cases sputum tests followed X-ray examination and proved TB. 19.6% (10.8-32.7) of PW were smear positive. XpertMTB/RIF was available for examining 23 patients and was positive 95.7% (77.3-99.9). 56.9% (43.3-69.5) PW were detected to have rifampicin sensitive TB, 37.3% (25.3-51.0) had primary MDR and 5.9% (1.4-16.5) had primary XDR. Thus, pregnancy is reasonable to be considered the risk factors of TB, only 12.2% (4.9-26.0) of HIV-negative PW had additio...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research

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Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
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