Asthma and Obstructive Sleep Apnea Syndrome (OSAS)

The objectives of this study is to determine the profile of patients with concomitant asthma and OSAS, the interrelationships between these two disorders and list the associated comorbidities.In this case-control study, two groups were compared: G1 = 158 asthmatics OSAS free ; G2 = 172 asthmatics with OSAS. The diagnostic criteria for OSAS are those recommended by the AASM.The frequency of OSAS is high (52%) and increased with age. It is more frequent in female (72%). In our study, the duration of asthma (> 10 years) is higher in G2 (89.5%) and its role in the occurrence and severity of OSAS is confirmed. The severity of OSAS is not always related to the severity of asthma. The clinical symptoms of asthma, its exacerbations and its low level of control are more frequent and more pronounced in the group with OSAS.The frequent inadequate control of asthma (90%) in severe OSAS is critical in its severity, as well. Several significant positive correlations (p<0,01) are observed between AHI and other parameters in G2 : BMI, unstable diabetes, frequency and severity of metabolic syndrome and others endocrinopathies.The results of our study help to corroborate the negative impact of OSAS on asthma but not to assert with certainty the precise role of each pathology in the etiopathogenesis of the other. Besides, the OSAS-Asthma mutual interrelationship can contribute to their reciprocal aggravation. Their respective and efficient prevention and / or management will undoubtedly a...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research