Sensitisation of the cough reflex in childbearing women to mechanical stimuli: a cross-sectional study

Background: The cough reflex in childbearing women has been found to be more sensitive to chemical stimuli than that in other populations. However, the effect of age and sex on the cough reflex threshold (CRT) triggered by mechanical stimuli has not been studied.Aim: Our objective was to explore the association between age and sex, and CRT triggered by mechanical stimuli (air pulses) in childbearing women using a previously validated laryngopharyngeal endoscopic esthesiometer and laser rangefinder (LPEER).Methods: A cohort of 118 subjects, half of whom were female (49%), aged 19-95 years (a mean of 55.7 years), were prospectively recruited from two tertiary care university hospitals. Subjects with upper aerodigestive symptoms, i.e., dysphagia, rhinitis, cough and gastroesophageal reflux (GER), and healthy subjects, were included. Factors that could potentially influence CRT were clinically assessed using standard case report forms and fibreoptic endoscopy. Dysphagia was evaluated using a fibreoptic endoscopic evaluation of swallowing. CRT was measured by delivering air pulses of increasing intensity to the aryepiglottic folds of the subjects using the LPEER connected to a thin fibreoptic bronchoscope. Multiple linear regression was performed adjusting for confounders.Results: The CRT curve between childbearing women and males of reproductive age deviated extensively, only converging after the age of 50 years. Female sex (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research

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Conclusion: Decidual vasculopathy at term contains the same CD56 positive extravillous endovascular trophoblasts seen with spiral artery remodeling in early pregnancy. CD56 may serve as a possible marker for decidual vasculopathy in the later stages of pregnancy. PMID: 32068473 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Authors: Chiba Y, Fukushima A, Nakao M, Kobayashi Y, Ishigaki T, Tenma T, Kamiya K, Shingu Y, Ooka T, Matsui Y, Anzai T Abstract A 23-year-old man had progressive muscle weakness and Emery-Dreifuss muscular dystrophy (EDMD) due to a LMNA (lamin A/C) mutation. Congestive heart failure diagnosed at 19 years of age. Maximal drug treatment/cardiac resynchronization failed to improve the cardiac function. He was therefore hospitalized due to heart failure. Despite extracorporeal membrane oxygenation, he developed severe right heart dysfunction and died (multiple organ failure). A cardiac lesion's presence determines the...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ConclusionsMRE is an efficient diagnostic tool in proper characterization of disease location in pediatric CD. As positive correlation of the results of MRE with the endoscopic and clinical activity has been found, taking into account good tolerance and non-invasiveness of the procedure it can be recommended to be used in reassessment.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
Authors: PMID: 32066585 [PubMed - in process]
Source: British Journal of Sports Medicine - Category: Sports Medicine Tags: Br J Sports Med Source Type: research
Publication date: March 2020Source: The Lancet Global Health, Volume 8, Issue 3Author(s): Stijn Van Hees, Stephen Raimon, Joseph Nelson Siewe Fodjo, Robert Colebunders
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
The aim of this study is to explore factors that determine infant removal by Child Protective Services and placement in out of home care, for methamphetamine-using women receiving pregnancy care with Western Australia Women and Newborn Drug and Alcohol Ser...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
BACKGROUND: Trauma is the leading cause of non-obstetric death in pregnancy. While maternal management is defined, few studies have examined the effects on the fetus. METHODS: Following IRB approval, all pregnant females (2010-2017) at a level-1 tr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
ConclusionCT was a more effective diagnostic tool for the diagnosis of irreversible gastric necrosis following caustic ingestion than a strategy based on digestive endoscopy and the use of CBSC. CT could eventually replace gastrointestinal endoscopy in the emergency evaluation of gastroesophageal caustic burns.
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
ConclusionDelayed postintubation tracheal stenosis should be taken into consideration, when a patient suffers from suffocating tracheal stenosis.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conditions:   Gastric Ultrasound;   Fasting ( 6H for Solid ; 2H for Clear Fluid );   Pregnant Women Intervention:   Sponsor:   University Hospital, Montpellier Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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