Short-acting bronchodilators for in-hospital management of acute exacerbation of COPD: Systematic Review

Introduction: No specific guidelines exist for administration of short-acting bronchodilator (SABD) for people hospitalised with acute exacerbation of chronic obstructive pulmonary disease (AECOPD); despite routine use in practice and risk of cardiac adverse events.Aim: To review evidence underpinning use and optimal dose, in terms of risk versus benefit, of SABD for inpatient management of AECOPD.Methods: A systematic search of Medline, Embase, CENTRAL and grey literature was conducted (up to December 2017) to identify relevant randomised controlled trials (RCT) or controlled clinical trials (CCT). Review methods were in accordance with PRSIMA guidelines and a pre-defined protocol.Results: Twelve studies were included. Four studies evaluated dose, finding no significant improvement in lung function with higher doses of SABD; However an RCT and a CCT reported significantly higher cardiac-related adverse events with a higher dose of SABD (both, p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research

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ConclusionsIn this short term observation study, INTELLiVENT-ASV selected ΔP and MP considered in safe ranges for lung protection. In a subgroup of ARDS patients, the combination of a recruitment strategy and INTELLiVENT-ASV resulted in an apparently safe ΔPL and MPL.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Condition:   Chronic Obstructive Pulmonary Disease Interventions:   Drug: Methylprednisolone;   Drug: Placebos Sponsor:   Versailles Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS:  The rapid development of home mechanical ventilation substantially impacts on the development of the hospital landscape in Germany. The exponential increase of these care-intensive patients is challenging for the health care system and requires a discussion about its limits. PMID: 31715635 [PubMed - in process]
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Let’s pretend the 195 nations that signed the 2016 Paris Climate Accord really do take all of the steps necessary to reach the agreement’s key goal: limiting the increase in global temperature to 1.5°C above pre-industrial levels. In that world, any children born today would grow up to witness some happy milestones. If they lived in the United Kingdom, they’d see their country phase out the use of coal by the time they turned six. If they lived in France, they would see gasoline-powered cars eliminated by their 21st birthday. And, as all of the 195 countries similarly reached their individual targets,...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Children climate change embargoed study Environment global warming health Source Type: news
We would like to congratulate the authors of the recent study entitled "Oxygen compared to air during exercise training in COPD with exercise-induced desaturation" for conducting a methodologically well-designed randomised controlled trial (RCT) [1]. The potential effects of several adjuncts to exercise training during pulmonary rehabilitation, such as supplemental oxygen or inspiratory muscle training, are still a matter for debate [2]. Additional improvements in functional capacity are only likely to occur when the adjunct interventions enable patients to train at higher intensities during their general exercis...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research
We thank D. Langer and R. Gosselink for their correspondence about our study [1]. They raise some interesting points, mainly related to training intensity.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research
In this study using nationwide administrative data in Japan, machine learning models improved the prediction of 30-day readmission after COPD hospitalization compared with a conventional model.AbbreviationsADLactivities of daily livingCOPDchronic obstructive pulmonary diseaseCMSCenters for Medicare and Medicaid ServicesDPCDiagnosis Procedure CombinationICD-10-CMInternational Classification of Diseases, Tenth Revision, Clinical ModificationROCreceiver-operating-characteristic. PMID: 31709851 [PubMed - as supplied by publisher]
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Authors: Vikjord SAA, Brumpton BM, Mai XM, Bhatta L, Vanfleteren L, Langhammer A Abstract In individuals with chronic obstructive pulmonary disease (COPD), the presence of comorbidities is associated with increased mortality risk. We wanted to study the association between bone mineral density (BMD) and mortality among individuals with COPD in a population-based cohort study. Participants were recruited from the second (1995-1997) and third (2006-2008) surveys of the HUNT Study and followed until February 2019. Hip and forearm BMD were included as continuous T-scores or categorized according to WHO criteria (normal...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Researchers from Colorado have proposed expanding the diagnostic criteria for...Read more on AuntMinnie.comRelated Reading: U.K. group uses math to characterize lung disease on CT Genetic variation in lung airways elevates risk of COPD COPD severity mirrors lung cancer incidence AJR: Ultralow-dose CT can evaluate COPD Emphysema-related COPD on CT signals higher malignancy risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
ConclusionThis study revealed the current status of lung diseases potentially related to tobacco smoking in Fukuoka Prefecture. Both COPD and CPFE were highly related to tobacco smoking, whereas 30% of patients with IIPs had never smoked.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
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