Valved holding chambers vary considerably in drug delivery efficacy
Conclusion: The evident difference in drug delivery with VHCs has potentially great consequences regarding successful treatment of children with bronchoconstriction. There is a need for comprehensive and financially independent testing and standardisation of VHCs.
A subspecialist friend of mine once told me, in jest, “get an organ” as we were debating over which of us should manage a disease that overlapped in both of our specialties. However, to do so is impossible in the field of allergy. As allergist-immunologists, we quickly came to understand that allergic diseases are immunologic, and by definition, in volve the entire body. It is true that many allergic diseases manifest predominantly in 1 organ, such as asthma involving the lung or atopic dermatitis involving the skin, yet all allergic diseases are systemic.
Publication date: Available online 18 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Anna Kornafeld, David Abia-Trujillo, Sebastian Fernandez-Bussy, Isabel Mira-Avendano, Alexei Gonzalez-Estrada
AbstractThe European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI include (i) supporting health promotion in which the prevention of allergy and asthma plays a critical role and (ii) disseminating the knowledge of allergy to all stakeholders including the EAACI junior members. Substantial progress was made in 2018 in the identification of basic mechanisms of atopic dermatitis and urticaria and the translation of t hese mechanisms into clinics. Many large epidemiologic studi...
Children are more prone to developing allergic asthma than adults. Wang et al. find that sympathetic nerves undergo a dopaminergic-to-adrenergic transition during post-natal development of the lung. Dopamine signaling in CD4+ T cells promotes a Th2 phenotype, which makes young mice more susceptible to allergy. These findings provide an age-related mechanism underlying t he susceptibility of the young to allergic inflammation.
Beliefs about one ’s illness or “illness perceptions”, such as severity, chronicity or degree of control over illness have been shown to be related to long term reported health status, psychological wellbeing and treatment outcomes across a range of physical health conditions (1) and to adherence in asthma (2). Difficult to treat asthma (DTA) is a broad disease describing persistent symptoms despite maximised standard treatment (3). The psychiatric morbidity in DTA is recognised (4); however, the specifics about how people relate to their illness are less well understood.
The issue of health disparities is a quite broad, far reaching topic that encompasses many factors including age, race, ethnicity, gender and socioeconomic status. Also, health disparities exist by place (urban, rural, state) and disability status. The National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC) and other federal agencies collaborated with the Agency for Healthcare Research and Quality (AHRQ) to produce the National Healthcare Quality and Disparities Report.
This article reviews the latest developments in conditioning regimens for primary immunodeficiency (PID). It focuses on data regarding transplant outcomes according to newer reduced toxicity conditioning regimens used in HCT for PID.Recent FindingsConventional myeloablative conditioning regimens are associated with significant acute toxicities, transplant-related mortality, and late effects such as infertility. Reduced toxicity conditioning regimens have had significant positive impacts on HCT outcome, and there are now well-established strategies in children with PID. Treosulfan has emerged as a promising preparative agen...
Cow ’s milk allergy is very common affecting between 2% and 3%, and in some reports up to 7%, of young infants and children1. It has been found that approximately 75% of cow’s milk allergic children are able to tolerate heated cow’s milk, such as in baked goods, while remaining reactive to unheate d milk2-4. In addition, regular consumption of heated cow’s milk may hasten the development of tolerance to unheated cow’s milk in a proportion of cow’s milk allergic children5.
Guidelines recommend prompt use of intramuscular epinephrine as first-line treatment for anaphylaxis 1-5. Patients at-risk of anaphylaxis are generally couselled by medical professionals to carry epinephrine in the form of an epinephrine auto-injector (EAI) to treat a severe allergic reaction. Despite its critical role as a life-saving medication, availability of EAIs differs around the world. Shortages of EAIs have compounded this problem.