Neural crest contributions to the ear: Implications for congenital hearing disorders.

Neural crest contributions to the ear: Implications for congenital hearing disorders.
Hear Res. 2018 Nov 14;:
Authors: Ritter KE, Martin DM
Abstract
Congenital hearing disorders affect millions of children worldwide and can significantly impact acquisition of speech and language. Efforts to identify the developmental genetic etiologies of conductive and sensorineural hearing losses have revealed critical roles for cranial neural crest cells (NCCs) in ear development. Cranial NCCs contribute to all portions of the ear, and defects in neural crest development can lead to neurocristopathies associated with profound hearing loss. The molecular mechanisms governing the development of neural crest derivatives within the ear are partially understood, but many questions remain. In this review, we describe recent advancements in determining neural crest contributions to the ear, how they inform our understanding of neurocristopathies, and highlight new avenues for further research using bioinformatic approaches.
PMID: 30455064 [PubMed - as supplied by publisher]

Source: Hearing Research - November 14, 2018 Category: Audiology Authors: Ritter KE, Martin DM Tags: Hear Res Source Type: research