Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation,steatosis,and insulin resistance in diet-induced obesity.

In conclusion, up-regulation of hepatic GPI-PLD in diabetic conditions leads to DAG accumulation in liver by shedding GPI anchors intracellularly, which may play a causal role in impaired hepatic insulin signaling and progression of NAFLD.
PMID: 30457913 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Endocrinology and Metabolism - November 20, 2018 Category: Physiology Authors: Masuda S, Fujishima Y, Maeda N, Tsugawa-Shimizu Y, Nakamura Y, Tanaka Y, Obata Y, Fukuda S, Nagao H, Kita S, Nishizawa H, Shimomura I Tags: Am J Physiol Endocrinol Metab Source Type: research