Choosing a Reduced Intensity Conditioning Regimen for Allogeneic Stem Cell Transplantation, Fludarabine Busulfan versus Fludarabine Melphalan: A Systematic Review and Meta-analysis

Allogeneic hematopoietic stem cell transplantation (HCT) has evolved as a potential curative therapy for various hematological malignancies [1, 2]. Regimen-related toxicity and transplant-related mortality preclude the use of conventional myeloablative conditioning (MAC) regimens in patients who are older or have a poorer functional status. Reduced intensity conditioning (RIC) regimens have extended the use of HCT in older and less fit patients, who are not able to tolerate MAC regimens with HCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research