STAM-binding protein regulates melanoma metastasis through SLUG stabilization.

In this study, we demonstrate that STAMBP is a key molecule for regulating melanoma migration and invasion, but not survival, by knocking down STAMBP in vitro. STAMBP regulates SLUG expression through a post-transcriptional mechanism to control protein stability and further contributes to the in vivo metastatic potential of melanoma. Collectively, these results indicate the importance of STAMBP in melanoma metastasis by regulating SLUG. It is therefore a potential therapeutic target. PMID: 30454887 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30454887?dopt=Abstract

Source: Biochemical and Biophysical Research communications - November 16, 2018 Category: Biochemistry Authors: Iwakami Y, Yokoyama S, Watanabe K, Hayakawa Y Tags: Biochem Biophys Res Commun Source Type: research