Non-pharmacological interventions for agitation/aggressive behaviour in patients with dementia: a randomized controlled crossover trial.

Non-pharmacological interventions for agitation/aggressive behaviour in patients with dementia: a randomized controlled crossover trial. Funct Neurol. 2018 Jul/Sept;33(3):143-147 Authors: Dimitriou TD, Verykouki E, Papatriantafyllou J, Konsta A, Kazis D, Tsolaki M Abstract Agitation/aggressive behaviour is a common behavioural and psychological symptom in people with dementia (PwD), occurring with a frequency of between 13-50.4% according to recent studies, and the rate increases as the severity of cognitive decline increases. The burden on caregivers is considerable. This trial is a randomized controlled crossover trial conducted in Greece. The following measures were used: the Mini-Mental State Examination, Addenbrooke's Cognitive Examination Revised, Geriatric Depression Scale, Functional Rating Scale for Symptoms in Dementia and Neuropsychiatric Inventory. According to the results the most effective nonpharmacological intervention for reducing agitation/aggressive behaviour in PwD was music therapy, followed by aromatherapy and massage, and finally physical exercise. PMID: 30457967 [PubMed - in process]
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research

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CONCLUSIONS: Individually customized, multicomponent exercise programs lead to improved levels of cognitive function, depression, and quality of life, especially among those who are more frail. PMID: 33029968 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Purpose of review The present review aims to address the clinical benefits of using nicotinamide riboside, a precursor to the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD+) as a therapeutic agent to attenuate age-related cognitive decline. Recent findings Oral supplementation with nicotinamide riboside can inhibit the accumulation of pathological hallmarks of Alzheimer's disease and improve learning and memory in various murine models for dementia. Nicotinamide riboside can also reduce DNA damage, neuroinflammation, apoptosis, and improved hippocampal synaptic plasticity in diabetic mice, and ...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: MICRONUTRIENT SUPPLEMENTATION AND FUNCTIONAL FOODS: Edited by Nathalie M. Delzenne and Henry C. Lukaski Source Type: research
This study also found that a number of patients with COVID suffered strokes. In fact, COVID infection is a risk factor for strokes. A group of Canadian doctors found that individuals over 70 years of age were at particularly high risk for stroke related to COVID infection, but even young individuals are seven times more likely to have a stroke from this coronavirus versus a typical flu virus. Autopsy data from COVID patients in Finland suggests that another major cause of brain damage is lack of oxygen. Particularly worrisome is that several of the patients who were autopsied did not show any signs of brain injury during t...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Brain and cognitive health Coronavirus and COVID-19 Memory Neurological conditions Source Type: blogs
Depression, especially in old age, has been consistently associated with increased dementia incidence1,2, though it is still unclear whether depression is a risk or causal factor for dementia or merely a presenting symptom3. The evidence on the relationship of depression, and specifically its subtle presentations, with clinical entities that precede dementia, namely cognitive decline and mild cognitive impairment (MCI), is less consistent, with the majority of evidence indicating that depression and depression symptoms predict incident MCI4,5 and faster cognitive decline6.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
CONCLUSION: Currently, the limited evidence on the usability and usefulness of mHealth within dementia caregiver populations indicates that mHealth holds promise as an intervention platform and warrants continued investigation. PMID: 33006526 [PubMed - as supplied by publisher]
Source: Assistive Technology - Category: Rehabilitation Tags: Assist Technol Source Type: research
Alzheimer's Society's new report,'Worst hit: dementia during coronavirus', says Government must fix social care now, learning lessons to avoid further winter tragedy, as dementia carers struggle with depression, insomnia and exhaustion. Since coronavirus (COVID-19) lockdown on 23 March, an Alzheimer's Society investigation has discovered family and friends have spent an extra 92 million hours caring for loved ones with dementia1, due to the double whammy of lockdown making dementia symptoms worse, and the chronically underfunded social care system leaving them nowhere else to turn.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Authors: Smith PF Abstract Dementia is recognised to be one of the most challenging diseases facing society, both now and in the future, with its prevalence estimated to increase substantially by 2050. The potential contributions of age-related sensory deficits have attracted little attention until recently, when a landmark study suggested that hearing loss could be a greater risk factor for dementia than hypertension, obesity, smoking, depression, physical inactivity or social isolation. Over the last decade, evidence has been gradually accumulating to suggest that the other part of the inner ear, the balance orga...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
The objective of this review was to summarize the findings of the INPH-CRasH study. METHODS: VRFs, comorbidities, QOL, and adverse events were analyzed in consecutive patients with INPH who underwent shunt placement between 2008 and 2010 in 5 of 6 neurosurgical centers in Sweden. Patients (n = 176, within the age span of 60-85 years and not having dementia) were compared to population-based age- and gender-matched controls (n = 368, same inclusion criteria as for the patients with INPH). Assessed parameters were as follows: hypertension; diabetes; obesity; hyperlipidemia; psychosocial factors (stress and depression); ...
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
Clinicians hope that sex will increasingly be considered in clinical trial design and in treating cardiovascular disease comorbid with dementia and depression.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news
Authors: Carty CL, Noonan C, Muller C, Saner D, Reiman EM, Buchwald D, Bell RA, Nelson LA Abstract The burden of Alzheimer's disease and related dementias (ADRD) has increased substantially in the United States, particularly in health disparity populations. Little is known about the epidemiology of ADRD in American Indian (AI) adults, although they have a high prevalence of ADRD risk factors including hypertension, diabetes, obesity, and smoking. Using electronic health records from a large health care organization during 2016-18, we describe characteristics of AI patients aged ≥55 years with and without an ADRD...
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
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