Diagnostics Are Helping Counter Antimicrobial Resistance, But More Work Is Needed

Antimicrobial resistance (AMR) threats to patient health are becoming more widely recognized and diagnostics manufacturers are making significant progress in combatting the overuse of antibiotics. There is still a lot of work to be done, however. A recent health scare for Rick Bright, Ph.D., director of the Biomedical Advanced Research and Development Authority (BARDA), HHS, the very agency working to combat emerging infectious diseases (EID) and other threats, highlights the lingering risks.  During the 10th Public Meeting of the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) in September, Bright recounted his own experience with a multidrug-resistant organism (MDRO). Having contracted the MDRO from a scratch while gardening, he ended up seeking treatment from a number of urgent care clinics before finding one that would treat and culture the wound. According to minutes from the council meeting, Bright described facing potential surgery and even amputation of his thumb. “Costly” rounds of two new antibiotics eventually proved effective, but Bright had to work to track down his culture results, which were positive for methicillin-resistant Staphylococcus aureus (MRSA), he shared.  “The experience demonstrates the need for new standard procedures, such as immediate culturing and point-of-care diagnostics in the emergency department, so providers can prescribe the r...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news

Related Links:

Authors: Harada K, Yasuda M, Hasegawa K, Yamazaki Y, Sasano H, Otsuka F Abstract Adrenocortical carcinoma (ACC) is a rare malignancy arising from adrenocortical parenchymal cells. Myxoid ACC is one of the newly identified, rare, but important histological variants of ACC, characterized by the presence of abundant extracellular Alcian Blue-positive myxoid material. Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant cancer predisposition syndrome, and the incidence of ACC in MEN1 patients has been reported to be between 1.4% and 6%. Here, we report the case of a 68-year-old Japanese woman harboring t...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
This study aimed to investigate if hyperinsulinemia and/or insulin resistance was correlated with the occurrence of papillary thyroid cancer (PTC) in a group of Chinese patients. 258 inpatients were included in the study. According to the postoperative pathology results, all subjects were divided into PTC (n = 153) and control groups (with benign thyroid nodules, n = 105). Body mass index (BMI), fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), thyroid-stimulating hormone (TSH), FT4, FT3, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb), serum uric acid (UA), ...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Authors: Procaccio L, Bergamo F, Manai C, Di Antonio V, Fassan M, Zagonel V, Lonardi S, Loupakis F Abstract Introduction: Lung metastases occur in 10-20% of patients with colorectal cancer (CRC). Most of them are treated with palliative intent and have a poor prognosis. Pulmonary metastasectomy may be a curative option for carefully selected patients with 5-year survival rates ranging from 25% to 60%. However, up to 70% of patients develop recurrence after pulmonary metastasectomy. Therefore, the identification of prognostic factors is essential in CRC patients with resectable lung metastases. Areas covered: This r...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Authors: Snijder J, Peraza J, Padilla M, Capaccione K, Salvatore MM Abstract Introduction: Idiopathic pulmonary fibrosis (IPF) is a relentless form of fibrotic lung disease with a median survival of approximately 3 years after diagnosis and a mortality rate that surpasses that of many types of cancer. The pathophysiology of IPF is complex as there are likely different stages of disease occurring simultaneously in the lung. Areas covered: Some scientists consider IPF as primarily an epithelial driven disease in which dysfunctional surfactant-producing cells take an etiological precedent. Others focus on the augmente...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
This study involved patients from the North-East Indian population, where the numbers of reported cases are increasing rapidly and alarmingly. Oxidative stress, based on 8-OH-dG levels, was found to be significantly higher in gallbladder anomalies (cholelithiasis [CL] and cholecystitis [CS]) and GBC at the plasma and DNA level, and was associated with GBC severity. The expressions of key BER pathway genes were downregulated in gallbladder anomalies and GBC compared to controls, and in GBC compared to both non-neoplastic controls and gallbladder anomalies. Expression of XRCC1 and hOGG1 was significantly associated with both...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Conclusions: A large number of mouse and rat cognitive testing measures have been reported for a variety of particle species and energies for acute doses. However tissue reactions occur above dose thresholds and very few studies were performed at the heavy ion doses to be encountered on space missions (
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Publication date: Available online 23 May 2019Source: Life SciencesAuthor(s): Huanxiang Jia, Ming Xu, Yan Bo, Wenxiao Li, Runhe ZhouAbstractAimsExtracellular signal-regulated protein kinases 1 and 2 (ERK1/2) is a key downstream gene of Ras pathway. Activation of Ras-ERK1/2 has been testified to be linked to the progression of diverse cancers. Nonetheless, whether Ras-ERK1/2-tumorigenic pathway is mediated by epigenetic factors remains indistinct. The purpose of the research attempted to disclose the functions of H2BK5ac in Ras-ERK1/2-evoked CRC cell phenotypes.Materials and methodsWestern blot assay was implemented for exp...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionsOur results demonstrated that there are novel HPVs present in oral rinse samples that may be associated with OCC and OPC. These novel HPVs can be identified and characterized using NGS techniques.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research
Publication date: Available online 23 May 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Andrei Sakai, Ana Paula de Sousa Mesquista, Erica Valadares de Castro Levatti, Anita Hilda Straus, Helena B. Nader, Carla Cristina Lopes, Luciano CaseliAbstractTrastuzumab (Tmab) is a monoclonal antibody administered as targeted therapy for HER2-positive breast cancer whose molecular interactions at the HER2 receptor microenvironment are not completely clarified yet. This paper describes the influence of Tmab in the molecular organization of films of biological-relevant molecules at the air water interface. Fo...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Publication date: July 2019Source: Microchemical Journal, Volume 148Author(s): Shekher Kummari, V. Sunil Kumar, M. Satyanarayana, K. Vengatajalabathy GobiAbstractChemotherapy is a widely used effective method for the treatment of cancer in humans. Severity of dose levels and treatment duration necessitate frequent continuous monitoring of active drug concentration in human serum and urine. Development of an electrochemical biosensor for direct determination of methotrexate (MTX), a chemotherapy agent, from physiological fluids has been investigated. Functionalized multi-walled carbon nanotube paste electrodes (f-CNTPE) hav...
Source: Microchemical Journal - Category: Chemistry Source Type: research
More News: Antibiotic Therapy | Antimicrobial Resistance | Cancer | Cancer & Oncology | Emergency Medicine | Environmental Health | Genetics | Hepatitis | Hepatitis C | Hospitals | Infectious Diseases | Laboratory Medicine | Medical Devices | MRSA | Multidrug Resistance | National Institutes of Health (NIH) | Respiratory Medicine | Septic Shock | Staphylococcus Aureus | Study | Superbugs