Detecting impaired function of renal allografts at the early stage after transplantation using intravoxel incoherent motion imaging.

CONCLUSION: IVIM technique may be useful for detecting renal allograft dysfunction, especially combined use of cortical parameters. PMID: 30450922 [PubMed - as supplied by publisher]
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

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Conclusions We present a quick, simple, and affordable method to decellularize a muscle flap through the vascular network. Our proposed method is efficient and can be completed in a significantly shorter time when compared with other methods. It is also safe and does not affect integrity of tissue, and this is essential for a reliable recellularization.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Transplantation Surgery and Research Source Type: research
Abstract BACKGROUND AND OBJECTIVES: Recent developments indicated that functional magnetic resonance imaging (MRI) could potentially provide noninvasive assessment of kidney interstitial fibrosis in patients with kidney diseases, but direct evidence from histopathology is scarce. We aimed to explore the diagnostic utilities of functional MRI for the evaluation of kidney allograft interstitial fibrosis. DESIGN, SETTING, PARTICIPANTS, &MEASUREMENTS: We prospectively examined 103 kidney transplant recipients who underwent for-cause biopsies and 20 biopsy-proven normal subjects with functional MRI. Histomorph...
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
Jacopo Pizzicannella1†, Agnese Gugliandolo2†, Tiziana Orsini3, Antonella Fontana4, Alessia Ventrella4, Emanuela Mazzon2*, Placido Bramanti2, Francesca Diomede1‡ and Oriana Trubiani1‡ 1Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti–Pescara, Chieti, Italy 2IRCCS Centro Neurolesi “Bonino Pulejo,” Messina, Italy 3Institute of Cell Biology and Neurobiology, National Research Council, Rome, Italy 4Department of Pharmacy, “G. d’Annunzio” University of Chieti–Pescara, Chieti, Italy B...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractAimsCardiac allograft vasculopathy (CAV) is a leading cause of death in orthotopic heart transplant (OHT) survivors. Effective non-invasive screening methods are needed. Our aim was to investigate the added diagnostic and prognostic value of myocardial blood flow (MBF) to standard myocardial perfusion imaging (MPI) with positron emission tomography (PET) for CAV detection.Methods and resultsWe studied 94 OHT recipients (prognostic cohort), including 66 who underwent invasive coronary angiography and PET within 1  year (diagnostic cohort). The ISHLT classification was used as standard definition for CAV. Posi...
Source: European Heart Journal - Category: Cardiology Source Type: research
The lung allograft is dependent on the vascular supply to the transplanted lung which may be compromised during the surgical procedure. Arterial blood gases and portable chest x-rays may be poor predictors of the vascular supply in the immediate post-operative period. Perfusion lung scans may non-invasively assess the perfusion and physiological function in the immediate post-operative period and detect reversible vascular problems. The aim of this study was to illustrate the use and impact of the perfusion scan in the immediate post-operative period.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
PurposeTo examine the longitudinal changes of renal perfusion due to acute and chronic renal allograft rejection by using arterial spin labeling (ASL) MRI in translational mouse models of isogenic and allogenic kidney transplantation (ktx). Materials and MethodsAcute rejection was induced by allogenic ktx of C57BL/6 (B6)‐kidney grafts to BALB/c‐recipients with prolonged cold ischemia (CIT) of 60 minutes (n = 13). To induce chronic rejection BALB/c‐kidneys were transplanted into B6‐recipients with short CIT of 30 minutes (n = 22). Isogenic grafts without rejection (n = 14 wi...
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Original Research Source Type: research
ConclusionNuclear medicine techniques are strongly established as valuable clinical tools in a wide variety of indications, before and after organ transplantation. Furthermore,18F-FDG PET/CT in PTLD and radio-isotopic evaluation of the renal function in putative kidney donors are recommended in clinical algorithms proposed in international guidelines.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
an AK Abstract BACKGROUND: Different non-invasive imaging techniques such as Doppler ultrasonography and renal scintigraphy are commonly employed to assess allograft function and associated complications. However, all such methods lack sufficient specificity to discriminate between residual renal function of native kidneys. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) evaluates signal dynamics during the passage of contrast material through the renal cortex, medulla, and collecting system. PURPOSE: To investigate the value of DCE 3T MRI using a quantitative pharmacokinetic parameter (Ktrans)...
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research
In conclusion, pseudo-aneurysm of the renal transplant artery is a rare but potentially life-threatening complication of kidney transplantation, occurring even in the late post-transplant period. Surgical resection of the pseudo-aneurysm, although challenging, may be a valuable option for definitive treatment of the pseudo-aneurysm, while preserving the renal graft function. KEY WORDS: Aneurysm, Deceased donor, Kidney transplantation, Pseudo-aneurysm, Renal artery Surgery, Vascular complications. PMID: 27319817 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Conclusions: Essential to clinical face transplant outcomes is the preparedness of the institution, multidisciplinary face transplant team, organ procurement organization, and solid organ transplant colleagues. A translational facial research procurement and solid organ recovery model serves as an educational experience to modify processes and address procedural, anatomical, and logistical concerns for institutions developing a clinical face transplantation program. This methodical approach best simulates the stressors and challenges that can be expected during clinical face transplantation. CLINICAL QUESTION/LEVEL OF EVI...
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Reconstructive: Head and Neck: Original Articles Source Type: research
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