Induced pluripotent stem cell line, IMGTi003-A, derived from skin fibroblasts of an intellectually disabled patient with ring chromosome 13

Publication date: Available online 20 November 2018Source: Stem Cell ResearchAuthor(s): T.V. Nikitina, A.G. Menzorov, A.A. Kashevarova, M.M. Gridina, A.A. Khabarova, S. Yakovleva Yu, M.E. Lopatkina, I.E. Pristyazhnyuk, S.A. Vasilyev, O.L. Serov, I.N. LebedevAbstractSkin fibroblasts from a patient with neurodevelopmental and speech delay, anxiety disorder, macrocephaly, microorchidism, multiple anomalies of internal organs and ring chromosome 13 were reprogrammed into induced pluripotent stem cells (iPSCs) to generate a clonal stem cell line IMGTi003-A (iTAF6-6). IMGTi003-A pluripotency was demonstrated by three germ layer differentiation capacity in vitro, and this cell line had a mosaic karyotype with 46,XY,r(13) as a predominant cell subpopulation. IMGTi003-A line is a good model for studying of the mitotic instability of the ring chromosome 13.
Source: Stem Cell Research - Category: Stem Cells Source Type: research