Sympathetic overactivity in dialysis patients —Underappreciated and clinically consequential

AbstractCardiovascular morbidity and mortality remain frustratingly common in dialysis patients. A dearth of established evidence ‐based treatment calls for alternative therapeutic avenues to be embraced. Sympathetic hyperactivity, predominantly due to afferent nerve signaling from the diseased native kidneys, has been established to be prognostic in the dialysis population for over 15 years. Despite this, tangible therapeu tic interventions have, to date, been unsuccessful and the outlook for patients remains poor. This narrative review summarizes established experimental and clinical data, highlighting recent developments, and proposes why interventions to ameliorate sympathetic hyperactivity may well be beneficial f or this high‐risk population.
Source: Seminars In Dialysis - Category: Hematology Authors: Tags: REVIEW ARTICLE Source Type: research