Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

ConclusionIn conclusion, hypothalamic Pomc as well as Mc4r, both of which are reduced in type 1 diabetic mice, are required for normal counterregulatory responses to hypoglycemia. Therefore, enhancing MC4R function may improve hypoglycemia counterregulation in diabetes.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research