Galectins as potential emerging key targets in different types of leukemia.
Galectins as potential emerging key targets in different types of leukemia. Eur J Pharmacol. 2018 Nov 16;: Authors: Zheng Y, Feng W, Wang YJ, Sun Y, Shi G, Yu Q Abstract Galectins are carbohydrate-binding proteins and these have very high affinity for β-galactoside containing glycoproteins and glycolipids. Amongst sixteen types of galectin, the role of galectin 1, 3, 9 and 12 is defined in the development and progression of different types of leukemia including acute myeloid leukemia, acute promyelocytic leukemia, B-cell precursor acute lymphoblastic leukemia, adult T cell leukemia and chronic lymphocytic leukemia. There are multiple mechanisms through which these galectins may affect tumor proliferation. These may include increased production of tumor resistance conferring proteins such as multidrug resistance (MDR-1) and myeloid cell leukemia (MCL-1). Moreover, galectin-9 may act on Tim-3 receptors present on the circulating CD8+ T cells to impair immune system function and the latter provide an ideal environment for the proliferation of leukemic cells. The present review describes the role and mechanisms involved in galectin-mediated development and progression of different types of leukemia. PMID: 30452910 [PubMed - as supplied by publisher]
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Polly Soo Xi Yap, Azanna Ahmad Kamar, Chun Wie Chong, Ivan Kok Seng Yap, Cindy Shuan Ju Teh
Publication date: Available online 4 June 2020Source: Stem Cell ReportsAuthor(s): Baskar Ramdas, Raghuveer Singh Mali, Lakshmi Reddy Palam, Ruchi Pandey, Zhigang Cai, Santhosh Kumar Pasupuleti, Sarah S. Burns, Reuben Kapur
AbstractHigh-grade B cell lymphomas withMYC andBCL2 and/orBCL6 rearrangements ( “double-hit” lymphoma (DHL)/“triple-hit” lymphoma (THL)) are mature B cell neoplasms with highly aggressive clinical behavior and poor response to therapy. Lymphoblastic transformation of mature B cell neoplasms is an uncommon event that is best recognized for follicular lymphoma (FL). To ou r knowledge, only one case of “B lymphoblastic” transformation of de novo DHL has been reported in the literature. Here, we describe another case of such transformation. The patient was a 57-year-old man who presented wit...
In conclusion, 17p loss conferred a favorable impact on response rates, even among CK+ and MK+ patients that however could not be maintained. The effect ofTP53 mutations appeared to be different; however, patient numbers were low. Future research needs to further dissect the impact of the variousTP53 aberrations in HMA-based combination therapies. The limited duration of favorable responses to HMA treatment in adverse-risk genetics AML should prompt physicians to advance allografting for eligible patients in a timely fashion.
Today I'll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn't made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of...
Publication date: Available online 4 June 2020Source: Carbohydrate PolymersAuthor(s): Anh Q. Vo, Jiaxiang Zhang, Dinesh Nyavanandi, Suresh Bandari, Michael A. Repka
Publication date: Available online 4 June 2020Source: Carbohydrate PolymersAuthor(s): Fernanda R. Veregue, Hugo H.C. de Lima, Stéphanie C. Ribeiro, Marcelo S. Almeida, Cleiser T.P. da Silva, Marcos R. Guilherme, Andrelson W. Rinaldi
Publication date: Available online 4 June 2020Source: Carbohydrate PolymersAuthor(s): Hongyan Li, Jingyun Ji, Lu Yang, Ningyu Lei, Jing Wang, Baoguo Sun
Publication date: Available online 4 June 2020Source: Plant Physiology and BiochemistryAuthor(s): Tongtian Guo, Chen Tian, Chunyan Chen, Zhaoyang Duan, Qi Zhu, Luan Zi Sun
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.J ános P. Mészáros, Jelena M. Poljarević, István Szatmári, Oszkár Csuvik, Ferenc Fülöp, Norbert Szoboszlai, Gabriella Spengler, Éva A. Enyedy Synthesis and characterization of an 8-hydroxyquinoline –proline hybrid, and its complex formation with half-sandwich organometallic cations: aqueous chemistry, lipophilicity, cellular uptake and anticancer activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of thi...