CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis

ConclusionsGenerally, we identified that coverage of the association between SNPs ofCYP genes and anti-tuberculosis drug-related toxicity outcomes is incomplete. We observed significant associations between theRsaI and 96-bp deletion-insertion SNPs of theCYP2E1 gene and anti-tuberculosis drug-related hepatotoxicity. We were unable to comment on the impact of ethnicity on the investigated associations, as information on participants ’ ethnicity was sparsely reported in the included studies.Systematic review registrationPROSPERO registration number: CRD42017068448.
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research