Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis

ConclusionsThese results indicate that there exists a subpopulation of cells harboring gene amplification but withoutIDH1 mutation in the LGG primary cell pool. Further analysis of TCGA LGG database demonstrates that these regional chromosomal amplifications are also present in some cases of low grade gliomas indicating they are reoccurring lesions in glioma albeit at a low frequency. Taken together, these data suggest that regional chromosomal alterations may exist prior to the acquisition ofIDH mutations in at least some cases of LGGs.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research