Young females with long-standing patellofemoral pain display impaired conditioned pain modulation, increased temporal summation of pain, and widespread hyperalgesia

This study investigated antinociceptive and pronociceptive profiles in young females with long-standing (>5 years) PFP (current-PFP), those who recovered from adolescent PFP (recovered-PFP), and pain-free controls. This preregistered, assessor-blinded, cross-sectional study included 87 females younger than 25 years: 36 current-PFP, 22 recovered-PFP, and 29 pain-free controls. The primary outcome was conditioned pain modulation (CPM) assessed by increase of cuff pain thresholds during painful cuff conditioning on the contralateral leg. Secondary outcomes included pressure pain thresholds at the knee, shin, and forearm, and temporal summation of pain, assessed by pain intensity recordings on a visual analogue scale during repeated cuff pressure pain stimulations on the leg. Compared with the recovered-PFP, the current-PFP had impaired CPM (mean difference: 11.6%; P = 0.004) and reduced pressure pain thresholds at the knee, shin, and forearm which were also reduced compared to current-PFP (mean difference: 85-225 kPa; P
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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