Immediate-hypersensitivity reactions to proton pump inhibitors – experience in a medical department

Proton pump inhibitors (PPIs) are prescribed worldwide for the treatment of acid-peptic diseases1,2,3. They antagonize the enzyme H+/K+ ATPase in gastric cells, inhibiting acid secretion and raising gastric pH3,4. Side effects related to PPIs are reported in only 1-3% of treated patients1,5. Omeprazole, esomeprazole and pantoprazole have a similar chemical structure, differing from rabeprazole and lansoprazole1,5.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research