Germline genetic testing for inherited prostate cancer in practice: Implications for genetic testing, precision therapy, and cascade testing

ConclusionsA substantial proportion of men with PCA unselected for metastatic disease carry germline DNA repair PVs. Breast cancer family history and high Gleason score are important predictors to identify men with PCA who may carry germline DNA repair PVs. Our findings support current NCCN guidelines and have implications for genetic assessment, therapeutic management, and cascade testing for men with PCA and their families.

Source: The Prostate - November 18, 2018 Category: Urology & Nephrology Authors: Veda N. Giri, Sarah E. Hegarty, Colette Hyatt, Erin O'Leary, John Garcia, Karen E. Knudsen, William K. Kelly, Leonard G. Gomella Tags: ORIGINAL ARTICLE Source Type: research