Toxicity and in vivo release profile of sirolimus from implants into the vitreous of rabbits ’ eyes

ConclusionsIntravitreal PLGA or SRL-PLGA implants caused no significant reduction in cell viability and showed no evident toxic effect on the function or structure of the retina of the animals. SRL was released from PLGA implant after application in the vitreous of rabbits during 8  weeks.
Source: Documenta Ophthalmologica - Category: Opthalmology Source Type: research