Ak002, a novel siglec-8 antibody depletes human eosinophils and inhibits anaphylaxis in humanized mice

Pathologic accumulation and over-activation of mast cells and eosinophils have been implicated in certain allergic and inflammatory diseases. Siglec-8 is an inhibitory receptor selectively expressed on human eosinophils, mast cells, and, to a significantly lesser extent, basophils. Antibodies to Siglec-8 have the potential to be broadly anti-inflammatory by inducing apoptosis of eosinophils and inhibiting mast cell activation. AK002 is a novel, humanized, non-fucosylated IgG1 monoclonal antibody to Siglec-8.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: D400 Source Type: research