Exploratory analysis reveals positive correlation between c1 esterase inhibitor and serum complement 4 antigen levels

Low levels of C1-esterase inhibitor (C1-INH) and concomitant reduced complement 4 (C4) concentrations have been identified in patients with hereditary angioedema (HAE). C4 constitutes a promising candidate for a biomarker of disease activity. This investigation aims to determine the relationship between C1-INH functional activity levels (C1-INH[f]) and C4 antigen concentrations in patients with HAE treated with subcutaneous (SC) C1-INH, inferring significance for clinical practice.

Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: B. Zuraw, I. Jacobs, I. Pragst, H. Feuersenger, J. Chiao, T. Machnig, D. Pawaskar Tags: P160 Source Type: research