Rapid desensitization after a type i hypersensitivity reaction to ceftazidime/avibactam in a penicillin tolerant patient

Cerebral palsy patients are at high risk for developing recurrent pneumonia with increased morbidity and mortality. Frequent requirements of antibiotics have resulted in multidrug resistant (MDR) pathogens. Newer antibiotics can help treat these infections, but many contain beta lactam rings and less information is known about tolerability. This abstract describes a penicillin tolerant cerebral palsy patient who developed a type I hypersensitivity reaction to ceftazidime/avibactam, and his successful treatment with this antibiotic after rapid induction of temporary tolerance.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: M012 Source Type: research