Immunodeficiency in patients with myasthenia gravis and a thymoma
We describe two adult patients with Myasthenia Gravis and a thymoma who have undergone a total thymectomy and were found to have immune dysregulation.
Hello all, I'm a med peds resident who will begin an Allergy/Immunology fellowship next year (location TBD). I have grown more and more interested in health systems and the role of technology in patient care. I'd ultimately like to end up in a leadership role in my division or within a large health center. Given these interests and goals I've been considering pursuing an MBA. I wanted to see if anyone has done an MBA as part of fellowship? I am applying to some of the M7 fellowship programs... MBA during fellowship?
Publication date: Available online 17 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Philip H. Li, Timothy J. Watts, Ho-Yin Chung, Chak-Sing Lau
Publication date: Available online 18 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Di Sun, Peter Capucilli, Soma Jyonouchi
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Abstract Good's syndrome, the adult onset hypogammaglobulinemia associated with thymoma has been explained about six decades ago. It generally presents with recurrent infections and several paraneoplastic syndromes including myasthenia gravis, pure red cell aplasia, connective tissue disorders, superior vena cava, Horner's syndrome, lichen planus and inflammatory bowel disease. Lack of B cell, dysfunction of T cell, CD4+ T cell lymphopenia, reversed CD4/CD8+ T cell ratio, autoantibodies against Th17 related cytokines have been respected as the pathogenesis of the immune dysregulation this syndrome. A 57-year-old m...
Discussion Fatigue is a subjective feeling of decreased energy, tiredness or feeling of exhaustion. Lethargy is often used synonymously, but lethargy is a state of being drowsiness or sleepy, and implies mental status changes. Both can cause the person to be apathetic or less active. Fatigue is a common state that almost everyone experiences multiple times in his or her lifetime. For most people it is a relatively acute or short-term chronic problem, often with a relatively easily identifiable problem cause, such as inadequate sleep, acute illness, or overexertion. For some, it can be less readily identifiable such as dep...
Abstract Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system (CNS) with variable phenotypic presentations, while Guillain-Barre Syndrome (GBS) is the prototypic acute inflammatory disorder that affects the peripheral nervous system. Myasthenia gravis (MG) is a T cell dependent and antibody mediated autoimmune disease. Although it has been shown that complement plays a critical role in the pathogenesis of MS, GBS, and MG, the role of mannose-binding lectin (MBL) as a biomarker of immunopathogensis of these diseases and also its association with the severity of them have been po...