Dysfunctional DNA repair pathway via defective FANCD2 gene engenders multifarious exomic and transcriptomic effects in Fanconi anemia
ConclusionThese results underscore the consequences of defects in the DNA cross ‐link repair mechanism and indicate that accumulating diverse mutations from individual parent cells may make it difficult to anticipate the longitudinal clinical behavior of emerging disease states in an individual with FA.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Karthik Raja Velmurugan,
Pawel Michalak,
Lin Kang,
Natalie C. Fonville,
Harold R. Garner Tags: ORIGINAL ARTICLE Source Type: research