Stress Responses Against Rare Earth Ions Are Mediated by the JNK and p38 MAPK Pathways in Caenorhabditis elegans.

In this study, we found that both JNK- and p38-like MAPK pathways were involved in stress responses against RE. Unlike heavy metal responses, mutations in both the JNK and p38 pathways caused similar hypersensitivity to RE ions. Although the signaling pathways used for these stress responses were found to be similar, the degree of their respective contribution slightly differed between heavy metal and RE ions.
PMID: 30443708 [PubMed - as supplied by publisher]

Source: Biological Trace Element Research - November 15, 2018 Category: Biology Authors: Wakabayashi T, Nakano Y Tags: Biol Trace Elem Res Source Type: research