Light-triggered Covalent Assembly of Gold Nanoparticles for Cancer Cell Photothermal Therapy.

Light-triggered Covalent Assembly of Gold Nanoparticles for Cancer Cell Photothermal Therapy. Chembiochem. 2018 Nov 17;: Authors: Xia H, Gao Y, Yin L, Cheng X, Wang A, Zhao M, Ding J, Shi H Abstract Manipulating the assembly of gold nanoparticles (AuNPs) for maximizing the photothermal effect is a promising strategy for cancer therapy. Herein, taking advantage of the well-known tetrazole/alkene photo-click chemistry, we for the first time demonstrated that small AuNPs (23 nm) decorated with both 2, 5-diphenyltetrazole and methacrylic acid on the surface could form covalently cross-linked aggregates upon laser irradiation (λ = 405 nm). The in vitro studies indicated that the light-triggered assembling remarkably shifted the surface plasmon resonance of AuNPs to near-infrared (NIR) regions, which in consequence effectively enhanced the efficacy of photothermal therapy for 4T1 breast cancer cells. We thus believe that this new light-triggered assembly approach may offer a valuable tool for cancer treatment. PMID: 30447100 [PubMed - as supplied by publisher]
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research