GNAS, GNAQ, and GNA11 alterations in patients with diverse cancers

ConclusionsIn the current sample, the genesGNAS,GNAQ, andGNA11 were widely altered across cancer types, and these alterations often were accompanied by specific genomic abnormalities inAURKA,CBL, andLYN. Therefore, targetingGNA* alterations may require drugs that address the GNA* signal and important co ‐alterations.Cancer 2018;00:000 ‐000.© 2018 American Cancer Society.

Source: Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Austin J. Parish, Vi Nguyen, Aaron M. Goodman, Karthikeyan Murugesan, Garrett M. Frampton, Razelle Kurzrock Tags: Original Article Source Type: research