Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism.

CONCLUSIONS: These results revealed that promoting autophagy in PVAT improved endothelial function in response to alogliptin intervention. Additionally, the beneficial effect of alogliptin intervention on PVAT was GLP-1 dependent.
PMID: 30447331 [PubMed - as supplied by publisher]

Source: Vascular Pharmacology - November 14, 2018 Category: Drugs & Pharmacology Authors: Zhu B, Li Y, Mei W, He M, Ding Y, Meng B, Zhao H, Xiang G Tags: Vascul Pharmacol Source Type: research