Wish to die and reasons for living among patients with amyotrophic lateral sclerosis - Verschueren A, Kianimehr G, Belingher C, Salort-Campana E, Loundou A, Grapperon AM, Attarian S.

OBJECTIVE: In Amyotrophic lateral sclerosis (ALS), disease severity, ineffective treatment, and increasing dependence on caregivers may give rise to hopelessness and suicidal ideation among patients. In clinical practice, the desire for death among patient...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

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OBJECTIVE: The aim of this study was to determine in a systematic manner if the C9orf72 phenotype might extend beyond frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) to include psychiatric disease. METHODS: A validated ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionNine out of ten chronic neurological diseases were associated with an increased risk of suicide attempt. These data must be considered for clinicians treating this vulnerable group of patients.
Source: Journal of Neurology - Category: Neurology Source Type: research
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research
Conclusions:Compared to cancer patients as well as the all-cause DWD cohort in Oregon and Washington, more ALS patients used the prescribed aid-in-dying medications. Although they were a small percentage of the ALS patients participating with DWD, patients who did not use the medication were equally concerned about loss of dignity but were less concerned about being a burden on family, friends, or caregivers.Disclosure: Dr. Wang has received personal compensation for activities with Patient Care America as speaker. Dr. Elliott has nothing to disclose. Dr. Weiss has received personal compensation for activities with Walgree...
Source: Neurology - Category: Neurology Authors: Tags: Practice, Policy, and Ethics III Source Type: research
CONCLUSION: Respiratory failure was the most frequent cause of death in our cohort of ALS patients. In contrast, pneumonia and nutritional disorders played a less important role as the cause of death. The phenotypic expression of ALS might in part allow the cause of the prospective death to be predicted. Differentiation of ALS phenotypes is an important foundation for patient counseling on the process of dying to be expected and for the determination of an individual palliative concept. PMID: 28184974 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research
The question is not whether disruptive technologies will transform the healthcare job market, but rather how and when will it happen. Healthcare navigators, augmented/virtual reality operation planners and nanomedicine engineers in the second part of my article series about future jobs in healthcare. As I am certain that the huge waves of technological change transform the medical professional palette; based on the current and prospective trends in digital health technologies I envisioned what potential new professions could appear in our lives. Don’t miss the first part of the list! If you have an idea about another...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine artificial intelligence augmented reality brain-computer interface cyborg gamification gc4 Health Innovation nanotechnology Personalized medicine psychology robotics virtual reality Source Type: blogs
Conclusion: Smaller proportion of patients of ALS expressed death wish in India compared to the Western countries. This may be attributed to belief in religion/spirituality and karma, having meaning of life and family support. As this is the first report from India, useful information may be obtained if similar studies are done on a larger sample.
Source: Neurology India - Category: Neurology Authors: Source Type: research
Currently, 1 of every 6 Americans resides in a state where physician-assisted suicide/hastened death is legal, a denominator that appears to be shrinking.1 In 2015, fully half of state legislatures considered legalization of hastened death practices.1 These statistics are particularly relevant to neurologists who care for patients afflicted with amyotrophic lateral sclerosis (ALS). Hastened death interest among patients with ALS has been repeatedly reported both in the United States and in Western Europe, exceeding that of patients with other terminal illnesses by 2- to 10-fold.2–4 Among physicians who care for patie...
Source: Neurology - Category: Neurology Authors: Tags: Amyotrophic lateral sclerosis, Depression EDITORIALS Source Type: research
Patients with a new diagnosis of amyotrophic lateral sclerosis (ALS) may struggle with uncertainty about progression and the realization that they will lose key functions and how they will ultimately cope. Eventually, most lose abilities to talk, walk or transfer, swallow, and feed themselves, and are increasingly dependent on others. Thus, the diagnosis creates a complex psychodynamic and existential struggle based on current disabilities and future fears. It follows that patients with ALS elect physician-assisted death (PAD) with greater frequency than cancer.1,2
Source: Neurology - Category: Neurology Authors: Tags: Amyotrophic lateral sclerosis, Palliative care EDITORIALS Source Type: research
More News: ALS | Depression | Suicide