Effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly: Secondary analysis of a randomized, double-blind, placebo-controlled trial

Publication date: March–April 2014 Source:Mechanisms of Ageing and Development, Volumes 136–137 Author(s): Ondine van de Rest , Nikita L. van der Zwaluw , Michael Tieland , Jos J. Adam , Gert Jan Hiddink , Luc J.C. van Loon , Lisette C.P.G.M. de Groot Physical activity has been proposed as one of the most effective strategies to prevent cognitive decline. Protein supplementation may exert an additive effect. The effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly people was assessed in a secondary analysis. Two 24-week, double-blind, randomized, placebo-controlled intervention studies were carried out in parallel. Subjects performed a resistance-type exercise program of two sessions per week (n =62) or no exercise program (n =65). In both studies, subjects were randomly allocated to either a protein (2×15g daily) or a placebo drink. Cognitive functioning was assessed with a neuropsychological test battery focusing on the cognitive domains episodic memory, attention and working memory, information processing speed, and executive functioning. In frail and pre-frail elderly, resistance-type exercise training in combination with protein supplementation improved information processing speed (changes in domain score 0.08±0.51 versus −0.23±0.19 in the non-exercise group, p =0.04). Exercise training without protein supplementation was beneficial for attention and working memory...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research