Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

Publication date: March–April 2014 Source:Mechanisms of Ageing and Development, Volumes 136–137 Author(s): Aurelia Santoro , Elisa Pini , Maria Scurti , Giustina Palmas , Agnes Berendsen , Anna Brzozowska , Barbara Pietruszka , Anna Szczecinska , Noël Cano , Nathalie Meunier , C.P.G.M. de Groot , Edith Feskens , Susan Fairweather-Tait , Stefano Salvioli , Miriam Capri , Patrizia Brigidi , Claudio Franceschi The development of a chronic, low grade, inflammatory status named “inflammaging” is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65–79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research