The hallmarks of fibroblast ageing

Publication date: June 2014 Source:Mechanisms of Ageing and Development, Volume 138 Author(s): Julia Tigges , Jean Krutmann , Ellen Fritsche , Judith Haendeler , Heiner Schaal , Jens W. Fischer , Faiza Kalfalah , Hans Reinke , Guido Reifenberger , Kai Stühler , Natascia Ventura , Sabrina Gundermann , Petra Boukamp , Fritz Boege Ageing is influenced by the intrinsic disposition delineating what is maximally possible and extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic ageing processes act on the dermis, a post-mitotic skin compartment mainly consisting of extracellular matrix and fibroblasts. Dermal fibroblasts are long-lived cells constantly undergoing damage accumulation and (mal-)adaptation, thus constituting a powerful indicator system for human ageing. Here, we use the systematic of ubiquitous hallmarks of ageing (Lopez-Otin et al., 2013, Cell 153) to categorise the available knowledge regarding dermal fibroblast ageing. We discriminate processes inducible in culture from phenomena apparent in skin biopsies or primary cells from old donors, coming to the following conclusions: (i) Fibroblasts aged in culture exhibit most of the established, ubiquitous hallmarks of ageing. (ii) Not all of these hallmarks have been detected or investigated in fibroblasts aged in situ (in the skin). (iii) Dermal fibroblasts aged in vitro and in vivo exhibit additional features currently not considered ubiquitous hallmarks of a...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research