Inflamm-aging does not simply reflect increases in pro-inflammatory markers

Publication date: July 2014 Source:Mechanisms of Ageing and Development, Volume 139 Author(s): Vincent Morrisette-Thomas , Alan A. Cohen , Tamàs Fülöp , Éléonor Riesco , Véronique Legault , Qing Li , Emmanuel Milot , Françis Dusseault-Bélanger , Luigi Ferrucci Many biodemographic studies use biomarkers of inflammation to understand or predict chronic disease and aging. Inflamm-aging, i.e. chronic low-grade inflammation during aging, is commonly characterized by pro-inflammatory biomarkers. However, most studies use just one marker at a time, sometimes leading to conflicting results due to complex interactions among the markers. A multidimensional approach allows a more robust interpretation of the various relationships between the markers. We applied principal component analysis (PCA) to 19 inflammatory biomarkers from the InCHIANTI study. We identified a clear, stable structure among the markers, with the first axis explaining inflammatory activation (both pro- and anti-inflammatory markers loaded strongly and positively) and the second axis innate immune response. The first but not the second axis was strongly correlated with age (r =0.56, p <0.0001, r =0.08 p =0.053), and both were strongly predictive of mortality (hazard ratios per PCA unit (95% CI): 1.33 (1.16–1.53) and 0.87 (0.76–0.98) respectively) and multiple chronic diseases, but in opposite directions. Both axes were more predictive than any individual markers for baseline chronic di...

Source: Mechanisms of Ageing and Development - November 3, 2014 Category: Geriatrics Source Type: research