Effects of corneal injury on ciliary nerve fibre activity and corneal nociception in mice: A behavioural and electrophysiological study

ConclusionsOverall, this study provides new insights into the functional aspects of corneal nerve fibre activity in mice after corneal injury. The increase in ciliary nerve activity may thus contribute to the development of ocular pain after corneal damage.SignificanceThis study highlights the parallel increase in ciliary nerve activity and corneal sensitivity after corneal injury in mice. The strategy of combining ex vivo electrophysiological recordings of the ciliary nerve in mice and corneal sensitivity measurements therefore helps to uncover the functional aspects of corneal pain.

Source: European Journal of Pain - November 16, 2018 Category: Anesthesiology Authors: Fanny Joubert, Maria del Carmen Acosta, Juana Gallar, Darine Fakih, Jos é‐Alain Sahel, Christophe Baudouin, Laurence Bodineau, Stéphane Mélik Parsadaniantz, Annabelle Réaux‐Le Goazigo Tags: ORIGINAL ARTICLE Source Type: research