Unilesional mycosis fungoides is associated with increased expression of microRNA-17~92, and Th1 skewing.

CONCLUSIONS: Unilesional MF exhibits a microRNA profile distinct from conventional early MF, with a higher level of miR-17~92 members along with a Th1 skewing. These findings suggest a robust reactive T-cell immune response in unilesional MF and might account for the localized nature of this disease. This article is protected by copyright. All rights reserved. PMID: 30431147 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30431147?dopt=Abstract

Source: The British Journal of Dermatology - November 15, 2018 Category: Dermatology Authors: Moyal L, Gorovitz-Haris B, Yehezkel S, Jacob-Hirsch J, Bershtein V, Barzilai A, Rotem C, Sherman S, Amitay-Laish I, Feinmesser M, Hodak E Tags: Br J Dermatol Source Type: research